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Frailty in Older Adults Undergoing Aortic Valve Replacement: The FRAILTY-AVR Study.

Authors :
Rudski, Lawrence G.
Afilalo, Jonathan
Peterson, Mark D.
Arora, Rakesh C.
Noiseux, Nicolas
Rassi, Andrew
Palacios, Igor F.
Généreux, Philippe
Lindman, Brian R.
Asgar, Anita W.
Morais, José A.
Langlois, Yves
Morin, Jean-Francois
Popma, Jeffrey J.
Trnkus, Amanda
Perrault, Louis P.
Lauck, Sandra
Webb, John G.
Kim, Dae H.
Kim, Caroline A.
Source :
Journal of the American College of Cardiology (JACC). Aug2017, Vol. 70 Issue 6, p689-700. 12p.
Publication Year :
2017

Abstract

<bold>Background: </bold>Frailty is a geriatric syndrome that diminishes the potential for functional recovery after a transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) procedure; however, its integration in clinical practice has been limited by a lack of consensus on how to measure it.<bold>Objectives: </bold>This study sought to compare the incremental predictive value of 7 different frailty scales to predict poor outcomes following TAVR or SAVR.<bold>Methods: </bold>A prospective cohort of older adults undergoing TAVR or SAVR was assembled at 14 centers in 3 countries from 2012 to 2016. The following frailty scales were compared: Fried, Fried+, Rockwood, Short Physical Performance Battery, Bern, Columbia, and the Essential Frailty Toolset (EFT). Outcomes of interest were all-cause mortality and disability 1 year after the procedure.<bold>Results: </bold>The cohort was composed of 1,020 patients with a median age of 82 years. Depending on the scale used, the prevalence of frailty ranged from 26% to 68%. Frailty as measured by the EFT was the strongest predictor of death at 1 year (adjusted odds ratio [OR]: 3.72; 95% confidence interval [CI]: 2.54 to 5.45) with a C-statistic improvement of 0.071 (p < 0.001) and integrated discrimination improvement of 0.067 (p < 0.001). Moreover, the EFT was the strongest predictor of worsening disability at 1 year (adjusted OR: 2.13; 95% CI: 1.57 to 2.87) and death at 30 days (adjusted OR: 3.29; 95% CI: 1.73 to 6.26).<bold>Conclusions: </bold>Frailty is a risk factor for death and disability following TAVR and SAVR. A brief 4-item scale encompassing lower-extremity weakness, cognitive impairment, anemia, and hypoalbuminemia outperformed other frailty scales and is recommended for use in this setting. (Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions; NCT01845207). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07351097
Volume :
70
Issue :
6
Database :
Academic Search Index
Journal :
Journal of the American College of Cardiology (JACC)
Publication Type :
Academic Journal
Accession number :
124269334
Full Text :
https://doi.org/10.1016/j.jacc.2017.06.024