Back to Search
Start Over
Catalytic Enantioselective Aza-pinacol Rearrangement.
- Source :
-
Angewandte Chemie International Edition . 7/24/2017, Vol. 56 Issue 31, p9217-9221. 5p. - Publication Year :
- 2017
-
Abstract
- The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state involving a cyclic aza- ortho-xylylene intermediate to afford the indoline structures with good to excellent enantioselectivity. The synthetic utility of this method is demonstrated by the asymmetric synthesis of a key intermediate to the natural product minfiensine and the identification of a chiral lead compound to repress antibiotic resistance. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 56
- Issue :
- 31
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 124203460
- Full Text :
- https://doi.org/10.1002/anie.201705539