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Factor V Leiden and the risk for venous thromboembolism in the adult Danish population.
- Source :
-
Annals of Internal Medicine . 3/2/2004, Vol. 140 Issue 5, p330-337. 8p. 4 Diagrams, 2 Graphs. - Publication Year :
- 2004
-
Abstract
- <bold>Background: </bold>Odds ratios for venous thromboembolism (deep venous thrombosis and pulmonary embolism) derived from case-control studies range from 3 to 16 for heterozygotes compared with noncarriers and up to 79 for homozygotes compared with noncarriers.<bold>Objective: </bold>To estimate risks for venous thromboembolism in the adult Danish population according to factor V Leiden genotype.<bold>Design: </bold>Cohort study with 23 years of follow-up.<bold>Setting: </bold>Adult Danish population.<bold>Participants: </bold>9253 randomly selected individuals.<bold>Measurements: </bold>Hospitalization and death from venous thromboembolism, factor V Leiden genotype, and additional thromboembolic risk factors.<bold>Results: </bold>Adjusted hazard ratios in heterozygotes and homozygotes compared with noncarriers were 2.7 (95% CI, 1.8 to 3.8) and 18 (CI, 4.1 to 41) for venous thromboembolism overall, 2.4 (CI, 1.3 to 3.8) and 22 (CI, 0 to 60) for deep venous thrombosis, and 3.0 (CI, 1.7 to 4.9) and 11 (CI, 0 to 33) for pulmonary embolism. The lowest absolute 10-year risks for venous thromboembolism in factor V Leiden heterozygotes and homozygotes--0.7% (CI, 0.5% to 1.0%) and 3% (CI, 1% to 8%)--were found in nonsmokers younger than 40 years of age with a body mass index below 25 kg/m2; the corresponding highest risks--10% (CI, 7% to 14%) and 51% (CI, 13% to 100%)--were found in smokers older than 60 years of age with a body mass index above 30 kg/m2.<bold>Conclusions: </bold>Hazard ratios for venous thromboembolism in factor V Leiden heterozygotes and homozygotes compared with noncarriers in the adult Danish population were approximately 3 and 18, respectively. The simultaneous presence of smoking, obesity, and old age resulted in absolute 10-year thromboembolic risks of 10% in heterozygotes and 51% in homozygotes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THROMBOEMBOLISM risk factors
*VEINS
*BLOOD coagulation
*DANISH Americans
*OBESITY
Subjects
Details
- Language :
- English
- ISSN :
- 00034819
- Volume :
- 140
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Annals of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12404790
- Full Text :
- https://doi.org/10.7326/0003-4819-140-5-200403020-00008