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Interleukin-6 (IL6) Genotype Is Associated With Fat-Free Mass in Men But Not Women.
- Source :
-
Journals of Gerontology Series A: Biological Sciences & Medical Sciences . Dec2003, Vol. 58 Issue 12, p1085-1088. 4p. 1 Chart, 1 Graph. - Publication Year :
- 2003
-
Abstract
- We studied the association of the G-174C promoter polymorphism in the interleukin-6 gene (IL6) with total body fat and fat-free mass (FFM) in 242 men and women (IL6 genotypes: G/G, n = 87; G/C, n = 100; C/C, n = 55) across the adult age span (21-92 years). In men, but not women (significant genotype by sex interactions; p = .023-.048), the C/C group exhibited significantly lower total FFM than the G/G group (54.7 ± 0.8 kg vs 57.2 ± 0.7 kg, respectively, p = .020), as well as significantly lower FFM of the lower limbs compared with the G/G group (18.4 ± 0.3 kg vs 19.8 ± 0.3 kg, respectively, p = .004). No significant genotype differences were observed in total body fat mass in either men or women. The results indicate that the IL6 G-174C polymorphism is significantly associated with FFM in men but not women. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENETIC polymorphisms
*POPULATION genetics
*GENETICS
*PHENOTYPES
*INTERLEUKINS
Subjects
Details
- Language :
- English
- ISSN :
- 10795006
- Volume :
- 58
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 12395166
- Full Text :
- https://doi.org/10.1093/gerona/58.12.B1085