Pure Neuropsychiatric Presentation of Multiple Sclerosis.

This article focuses on two patients who were admitted to acute psychiatric inpatient units for new-onset manic behavior without any physical findings. Each received a comprehensive workup that included a psychiatric assessment, brain imaging, laboratory studies, lumbar punctures and neuropsychological testing. In both cases, the final diagnosis was multiple sclerosis. Multiple sclerosis is an inflammatory demyelinating illness that can affect any aspect of the central nervous system, including the cranial nerves.