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A t(11;20)(p15;q11) may identify a subset of nontherapy-related acute myelocytic leukemia
- Source :
-
Cancer Genetics & Cytogenetics . Mar2004, Vol. 149 Issue 2, p164. 5p. - Publication Year :
- 2004
-
Abstract
- A t(11;20)(p15;q11) is a rare but recurrent chromosomal aberration, reported in one case of polycythemia vera and a few cases of de novo acute myelocytic leukemia (AML) and therapy-related myelodysplastic syndrome (t-MDS). In t-MDS cases, the translocation resulted in the NUP98/TOP1 fusion transcript. The NUP98 gene has been suggested as the target for therapy-related malignancies. The reciprocal TOP1/NUP98 chimera, however, has not yet been encountered. We report a further case of de novo AML, subtype M2 in the French–American–British (FAB) classification, in which the reverse-transcriptase polymerase chain reaction (RT-PCR) revealed the NUP98/TOP1 chimera and also, for the first time, its reciprocal TOP1/NUP98. The literature review disclosed that, among six cases of de novo AML with t(11;20), the NUP98 gene was shown to be involved in one case and the NUP98/TOP1 chimera was detected in another. The translocation seems to be frequently associated with the FAB M2 subtype, younger age, hyperleukocytosis, and poor prognosis; thus, this translocation may identify a subset of not-therapy-related AML patients with shared clinical features. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01654608
- Volume :
- 149
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Genetics & Cytogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 12380016
- Full Text :
- https://doi.org/10.1016/j.cancergencyto.2003.07.002