TP53 and ATM mRNA expression in skin and skeletal muscle after low-level laser exposure.

Low-level lasers are widespread in regenerative medicine, but the molecular mechanisms involved in their biological effects are not fully understood, particularly those on DNA stability. Therefore, this study aimed to investigate mRNA expression of genes related to DNA genomic stability in skin and skeletal muscle tissue fromWistarrats exposed to low-level red and infrared lasers. For this,TP53(Tumor Protein 53) andATM(Ataxia Telangiectasia Mutated gene) mRNA expressions were evaluated by real-time quantitative PCR (RT-qPCR) technique 24 hours after low-level red and infrared laser exposure. Our data showed that relativeTP53mRNA expression was not significantly altered in both tissues exposed to lasers. ForATM, relative mRNA expression in skin tissue was not significantly altered, but in muscle tissue, laser exposure increased relativeATMmRNA expression. Low-level red and infrared laser radiations alterATMmRNA expression related to DNA stability in skeletal muscle tissue. [ABSTRACT FROM AUTHOR]