P 174 - Placental and mitochondrial Q10 content after CoQ10 supplementation during pregnancy.

Pre-eclampsia is a common disorder of human pregnancy (about 7% of all pregnancies) in which the normal hemodynamic response to pregnancy is compromised. In 2009, we demonstrated that supplementation with CoQ10 reduces significantly the risk of developing pre-eclampsia in women at risk for the condition. From these women, placental and mitochondrial Q10 levels, in women receiving either placebo or 200 mg CoQ10 daily were measured. Results showed that before supplementation, at week 20 of pregnancy, plasma CoQ10 levels showed no difference between the control (0.134±0.05 umol/l) and supplemented (0.139±0.06 umol/l) groups. Interestingly, at delivery, placental tissue showed no differences in the placebo group between women with normal pregnancy and those with preeclampsia; while in the Q10 group, women with preeclampsia showed significantly higher placental levels (0.31±0.20 ug/mg of protein) compared to normal pregnant women (0.18±0.08 ug/mg of protein; p=0.005). However, mitochondrial levels of Q10 in placenta from pregnant women with preeclampsia receiving placebo did not show differences compared to those receiving CoQ supplementation (0.82±0.41 vs. 0.77±0.42 ug/mg of protein). These results suggest that in women with preeclampsia, although CoQ10 reduced preeclampsia and increased its content in placental tissue, it is not able to increase the mitocondrial levels of CoQ10. [ABSTRACT FROM AUTHOR]