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Radiosynthesis and preliminary biological evaluation of Tc-labeled 2-methyl-2-pentylmalonic acid as an apoptosis imaging agent.
- Source :
-
Journal of Radioanalytical & Nuclear Chemistry . Jul2017, Vol. 313 Issue 1, p207-215. 9p. 2 Diagrams, 1 Chart, 3 Graphs. - Publication Year :
- 2017
-
Abstract
- Apoptosis is one of the fundamental phenomena behind successful radiation and chemotherapy treatments. Non-invasive imaging of apoptosis can offer an early diagnosis of disease and the true efficiency of an ongoing treatment procedure. The present study describes an attempt to develop Tc-labeled 2-methyl-2-pentylmalonic acid ([Tc] 8) as a new SPECT based apoptosis imaging agent. An optimized chemical and radiosynthesis procedure provided desired product [Tc] 8 with high radiochemical yield (84%, n = 3) and radiochemical purity (>99%) as determined by radio HPLC. Biodistribution data indicated that the radiotracer has a rapid clearance from blood and other background tissues. High testes accumulation confirmed the ability of the radiotracer to detect testicular apoptosis in mice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 313
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 123651937
- Full Text :
- https://doi.org/10.1007/s10967-017-5275-1