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Circularly permuted TRAIL plus thalidomide and dexamethasone versus thalidomide and dexamethasone for relapsed/refractory multiple myeloma: a phase 2 study.
- Source :
-
Cancer Chemotherapy & Pharmacology . Jun2017, Vol. 79 Issue 6, p1141-1149. 9p. - Publication Year :
- 2017
-
Abstract
- <bold>Purpose: </bold>Circularly permuted TRAIL (CPT) has exhibited promising efficacy as a mono-therapy or in combination with thalidomide for patients with multiple myeloma (MM). In this phase 2 study, the safety and efficacy of CPT in combination with thalidomide and dexamethasone (CPT + TD) was evaluated in patients with pretreated relapsed/refractory MM (RRMM).<bold>Methods: </bold>Patients who received at least two previous therapies for MM were randomly assigned at a 2:1 ratio to receive treatment with CPT + TD or thalidomide and dexamethasone (TD). The primary endpoint was the overall response rate (ORR), and the secondary endpoints included progression-free survival (PFS), duration of response (DOR) and safety.<bold>Results: </bold>Overall, 47 patients were assigned to the CPT + TD group, and 24 patients were recruited to the TD group. The ORR in the CPT + TD group was 38.3 vs. 25.0% in the TD group. The median PFS time was 6.7 months for the CPT + TD group and 3.1 months for the TD group. The median DORs for the CPT + TD and TD groups were 7.1 and 3.2 months, respectively. Most of the adverse effects (AEs) were grade 1 or 2. Serious AEs were reported in 19.7% of the patients. No treatment-related deaths were reported.<bold>Conclusion: </bold>CPT plus TD could serve as a new therapeutic strategy for patients with RRMM. A randomized, double-blind, placebo-controlled confirmatory study is currently under way. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THALIDOMIDE
*MULTIPLE myeloma treatment
*DEXAMETHASONE
*DISEASE relapse
*DRUG efficacy
*COMBINATION drug therapy
*THERAPEUTICS
*ANTINEOPLASTIC agents
*CARRIER proteins
*COMPARATIVE studies
*DRUG resistance in cancer cells
*RESEARCH methodology
*MEDICAL cooperation
*MULTIPLE myeloma
*PROGNOSIS
*RESEARCH
*EVALUATION research
*RANDOMIZED controlled trials
*BLIND experiment
Subjects
Details
- Language :
- English
- ISSN :
- 03445704
- Volume :
- 79
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Cancer Chemotherapy & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 123610534
- Full Text :
- https://doi.org/10.1007/s00280-017-3310-0