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Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer.
- Source :
-
BioMed Research International . 6/12/2017, Vol. 2017, p1-7. 7p. - Publication Year :
- 2017
-
Abstract
- Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related single nucleotide polymorphisms in breast cancer susceptibility remain unclear. This case-control study evaluated the associations between variants in the upstream transcription regulation region of miR-10b and the risk of breast cancer among Chinese women. Seven potentially functional SNPs were investigated using genotyping assays. The potential biological functions of the identified positive SNPs were further evaluated using in silico databases. We found that rs4078756, which was located at the promoter region of miR-10b, was significantly associated with breast cancer risk (rs4078756 AG/GG versus AA, adjusted odds ratio: 1.17, 95% confidence interval: 1.02–1.35). The other six single nucleotide polymorphisms exhibited negative associations. Based on the in silico prediction, rs4078756 potentially regulated miR-10b expression through promoter activation or repression. These findings indicate that a potentially functional SNP (rs4078756) in the promoter region of miR-10b may contribute to breast cancer susceptibility among Chinese women. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RNA physiology
*BREAST tumor risk factors
*ACADEMIC medical centers
*BREAST tumors
*CHI-squared test
*CHINESE people
*CONFIDENCE intervals
*GENE expression
*GENES
*GENETICS
*METASTASIS
*RESEARCH funding
*T-test (Statistics)
*LOGISTIC regression analysis
*CASE-control method
*DATA analysis software
*ODDS ratio
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2017
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 123543826
- Full Text :
- https://doi.org/10.1155/2017/2352874