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Cost-effectiveness of single versus double embryo transfer in IVF in relation to female age.

Cost-effectiveness of single versus double embryo transfer in IVF in relation to female age.

Authors :
van Loendersloot, Laura L.
Moolenaar, Lobke M.
van wely, Madelon
Repping, Sjoerd
Bossuyt, Patrick M.
Hompes, Peter G.A.
van der Veen, Fulco
Mol, Ben Willem J.
Source :
European Journal of Obstetrics & Gynecology & Reproductive Biology. Jul2017, Vol. 214, p25-30. 6p.
Publication Year :
2017

Abstract

<bold>Objective: </bold>To evaluate the cost-effectiveness of single embryo transfer followed by an additional frozen-thawed single embryo transfer, if more embryos are available, as compared to double embryo transfer in relation to female age.<bold>Study Design: </bold>We used a decision tree model to evaluate the costs from a healthcare provider perspective and the pregnancy rates of two embryo transfer policies: one fresh single embryo transfer followed by an additional frozen-thawed single embryo transfer, if more embryos are available (strategy I), and double embryo transfer (strategy II). The analysis was performed on an intention-to-treat basis. Sensitivity analyses were carried out to evaluate the robustness of our model and to identify which model parameters had the strongest impact on the results.<bold>Results: </bold>SET followed by an additional frozen-thawed single embryo transfer if available was dominant, less costly and more effective, over DET in women under 32 years. In women aged 32 or older DET was more effective than SET followed by an additional frozen-thawed single embryo transfer if available but also more costly.<bold>Conclusion: </bold>SET followed by an additional frozen-thawed single embryo transfer should be the preferred strategy in women under 32 undergoing IVF. The choice for SET followed by an additional frozen-thawed single embryo transfer or DET in women aged 32 or older depends on individual patient preferences and on how much society is willing to pay for an extra child. There is a strong need for a randomized clinical trial comparing the cost and effects of SET followed by an additional frozen-thawed single embryo transfer and DET in the latter category of women. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03012115
Volume :
214
Database :
Academic Search Index
Journal :
European Journal of Obstetrics & Gynecology & Reproductive Biology
Publication Type :
Academic Journal
Accession number :
123527824
Full Text :
https://doi.org/10.1016/j.ejogrb.2017.04.031