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Traumatic brain injury impairs sensorimotor function in mice.

Authors :
Sackheim, Adrian M.
Stockwell, David
Haines, Laurel
Russell, Sheila
Villalba, Nuria
Freeman, Kalev
Scott, Chary L.
Hammack, Sayamwong E.
Source :
Journal of Surgical Research. Jun2017, Vol. 213, p100-109. 10p.
Publication Year :
2017

Abstract

Introduction Understanding the extent to which murine models of traumatic brain injury (TBI) replicate clinically relevant neurologic outcomes is critical for mechanistic and therapeutic studies. We determined sensorimotor outcomes in a mouse model of TBI and validated the use of a standardized neurologic examination scoring system to quantify the extent of injury. Materials and methods We used a lateral fluid percussion injury model of TBI and compared TBI animals to those that underwent sham surgery. We measured neurobehavioral deficits using a standardized 12-point neurologic examination, magnetic resonance imaging, a rotating rod test, and longitudinal acoustic startle testing. Results TBI animals had a significantly decreased ability to balance on a rotating rod and a marked reduction in the amplitude of acoustic startle response. The neurologic examination had a high inter-rater reliability (87% agreement) and correlated with latency to fall on a rotating rod (R s = −0.809). Conclusions TBI impairs sensorimotor function in mice, and the extent of impairment can be predicted by a standardized neurologic examination. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00224804
Volume :
213
Database :
Academic Search Index
Journal :
Journal of Surgical Research
Publication Type :
Academic Journal
Accession number :
123501138
Full Text :
https://doi.org/10.1016/j.jss.2017.02.016