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Traumatic brain injury impairs sensorimotor function in mice.
- Source :
-
Journal of Surgical Research . Jun2017, Vol. 213, p100-109. 10p. - Publication Year :
- 2017
-
Abstract
- Introduction Understanding the extent to which murine models of traumatic brain injury (TBI) replicate clinically relevant neurologic outcomes is critical for mechanistic and therapeutic studies. We determined sensorimotor outcomes in a mouse model of TBI and validated the use of a standardized neurologic examination scoring system to quantify the extent of injury. Materials and methods We used a lateral fluid percussion injury model of TBI and compared TBI animals to those that underwent sham surgery. We measured neurobehavioral deficits using a standardized 12-point neurologic examination, magnetic resonance imaging, a rotating rod test, and longitudinal acoustic startle testing. Results TBI animals had a significantly decreased ability to balance on a rotating rod and a marked reduction in the amplitude of acoustic startle response. The neurologic examination had a high inter-rater reliability (87% agreement) and correlated with latency to fall on a rotating rod (R s = −0.809). Conclusions TBI impairs sensorimotor function in mice, and the extent of impairment can be predicted by a standardized neurologic examination. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00224804
- Volume :
- 213
- Database :
- Academic Search Index
- Journal :
- Journal of Surgical Research
- Publication Type :
- Academic Journal
- Accession number :
- 123501138
- Full Text :
- https://doi.org/10.1016/j.jss.2017.02.016