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Oxidative Deaminations and Deisatinylations of Ugi-Azide and Ugi-3CR Products: A Two-Step MCR-Oxidation Protocol toward Functionalized α-Ketoamides and α-Ketotetrazoles.
- Source :
-
Organic Letters . May2017, Vol. 19 Issue 9, p2238-2241. 4p. - Publication Year :
- 2017
-
Abstract
- A new postcondensation multicomponent reaction (MCR) methodology, comprising oxidative deaminations enabling access to multiple privileged carbonyl-containing scaffolds in two steps, is described. These protocols allow facile access to functionalized α-ketoamide and α-ketotetrazole small-molecule peptidomimetic-like building blocks from prototypical synthons with two points of diversity. Incorporation of chalcone and alkynyl moieties with further ring-forming reactions enables access to additional novel heterocyclic ring systems, including a unique and potentially highly pharmacologically relevant scaffold, a 1,2-selenazol-3(2H)-one. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OXIDATION
*MULTIPHASE flow
*CARBONYL compounds
*CHEMICAL reactions
*PHARMACOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 19
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 123353899
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b00710