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Polymorphism of ERK/PTPRR Genes in Major Depressive Disorder at Resting-State Brain Function.
- Source :
-
Developmental Neuropsychology . 2017, Vol. 42 Issue 3, p231-240. 10p. 4 Color Photographs, 4 Charts. - Publication Year :
- 2017
-
Abstract
- The polymorphism of ERK and PTPRR in MDD is rarely reported. The present study investigated the association between the polymorphism of ERK/PTPRR and MDD at resting-state brain function using genomic imaging. It indicated that the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) in functional magnetic resonance imaging (fMRI) changed significantly in various brain regions of MDD patients. The T/G allele of ERK-rs1267842 and G/C allele of PTPRR-rs1513105 showed abnormal ALFF and ReHo changes in cortex including superior frontal gyrus and middle temporal gyrus. The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 87565641
- Volume :
- 42
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Developmental Neuropsychology
- Publication Type :
- Academic Journal
- Accession number :
- 123351710
- Full Text :
- https://doi.org/10.1080/87565641.2017.1306527