Back to Search
Start Over
High-order epistasis shapes evolutionary trajectories.
- Source :
-
PLoS Computational Biology . 5/15/2017, Vol. 13 Issue 5, p1-16. 16p. - Publication Year :
- 2017
-
Abstract
- High-order epistasis—where the effect of a mutation is determined by interactions with two or more other mutations—makes small, but detectable, contributions to genotype-fitness maps. While epistasis between pairs of mutations is known to be an important determinant of evolutionary trajectories, the evolutionary consequences of high-order epistasis remain poorly understood. To determine the effect of high-order epistasis on evolutionary trajectories, we computationally removed high-order epistasis from experimental genotype-fitness maps containing all binary combinations of five mutations. We then compared trajectories through maps both with and without high-order epistasis. We found that high-order epistasis strongly shapes the accessibility and probability of evolutionary trajectories. A closer analysis revealed that the magnitude of epistasis, not its order, predicts is effects on evolutionary trajectories. We further find that high-order epistasis makes it impossible to predict evolutionary trajectories from the individual and paired effects of mutations. We therefore conclude that high-order epistasis profoundly shapes evolutionary trajectories through genotype-fitness maps. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EPISTASIS (Genetics)
*GENETIC mutation
*GENOTYPES
*GENE expression
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 1553734X
- Volume :
- 13
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- PLoS Computational Biology
- Publication Type :
- Academic Journal
- Accession number :
- 123047653
- Full Text :
- https://doi.org/10.1371/journal.pcbi.1005541