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Immunological and angiogenic markers during metronomic temozolomide and cyclophosphamide in canine cancer patients.
- Source :
-
Veterinary & Comparative Oncology . Jun2017, Vol. 15 Issue 2, p594-605. 12p. - Publication Year :
- 2017
-
Abstract
- Metronomic chemotherapy stimulates the immune response via depletion of regulatory T cells (Tregs) and suppresses angiogenesis by modulating the secretion of thrombospondin-1 ( TSP-1) and vascular endothelial growth factor ( VEGF). In this study, blood was collected from 10 healthy dogs and from 30 canine cancer patients before and 2 and 4 weeks after treatment with metronomic temozolomide (6.6 mg m−2), cyclophosphamide (12.5 mg m−2) or cyclophosphamide and temozolomide. The percentage of circulating CD25+Foxp3+ CD4+ Tregs and the plasma levels of TSP-1 and VEGF were measured. There was a significant difference in the percentage of Tregs between cancer patients and healthy dogs. A significant decrease in Tregs was noted in patients treated with metronomic cyclophosphamide and the combination. Treatment with temozolomide had no effect on the percentage of Tregs. TSP-1 and VEGF levels were, respectively, significantly lower and higher in cancer patients than in healthy dogs, but they were not influenced by any of the studied metronomic treatment regimens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14765810
- Volume :
- 15
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Veterinary & Comparative Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 122988043
- Full Text :
- https://doi.org/10.1111/vco.12203