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Factor de necrosis tumoral como marcador inflamatorio en pacientes con enfermedad pulmonar obstructiva crónica.

Authors :
Silva Paredes, Carlos
Miguel Bello, Luis
Source :
Archivos Venezolanos de Farmacología y Terapéutica. 2017, Vol. 36 Issue 1, p22-25. 4p.
Publication Year :
2017

Abstract

COPD is a chronic inflammatory disease that mainly affects bronchi less than 2 mm in diameter. This inflammation is an active and progressive mechanism with peaks of increase during exacerbations, and its deactivation becomes difficult as the disease progresses and structural damage is established. The inflammatory response is characterized by an increase in blood circulating inflammatory mediators such as CRP, fibrinogen, leukocytes, TNF (Tumor Necrosis Factor), and Interleukins 6 and 8. Tumor necrosis factor (TNF) is a central proinflammatory regulator of the immune system, and is produced primarily by activated macrophages. TNFa plays an important role in many inflammatory lung diseases, the most important of which are chronic obstructive pulmonary disease (COPD), asthma, acute lung injury and severe acute respiratory distress syndrome (ARDS). [ABSTRACT FROM AUTHOR]

Details

Language :
Spanish
ISSN :
07980264
Volume :
36
Issue :
1
Database :
Academic Search Index
Journal :
Archivos Venezolanos de Farmacología y Terapéutica
Publication Type :
Academic Journal
Accession number :
122891057