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Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy.
- Source :
-
Journal of Biomedical Optics . Apr2017, Vol. 22 Issue 4, p1-7. 7p. - Publication Year :
- 2017
-
Abstract
- Although the drug-eluting stent (DES) has dramatically reduced the rate of coronary restenosis, it still occurs in up to 20% of patients with a DES. Monitoring drug delivery could be one way to decrease restenosis rates. We demonstrate real-time photoacoustic imaging and spectroscopy (PAIS) using a wavelength-tunable visible laser and clinical ultrasound scanner to track cardiac drug delivery. The photoacoustic signal was initially calibrated using porcine myocardial samples soaked with a known concentration of a drug surrogate (DiI). Next, an in situ coronary artery was perfused with DiI for 20 min and imaged to monitor dye transport in the tissue. Finally, a partially DiI-coated stent was inserted into the porcine brachiocephalic trunk for imaging. The photoacoustic signal was proportional to the DiI concentration between 2.4 and 120 μg/ml, and the dye was detected over 1.5 mm from the targeted coronary vessel. Photoacoustic imaging was also able to differentiate the DiI-coated portion of the stent from the uncoated region. These results suggest that PAIS can track drug delivery to cardiac tissue and detect drugs loaded onto a stent with sub-mm precision. Future work using PAIS may help improve DES design and reduce the probability of restenosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10833668
- Volume :
- 22
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Biomedical Optics
- Publication Type :
- Academic Journal
- Accession number :
- 122889415
- Full Text :
- https://doi.org/10.1117/1.JBO.22.4.041016