Clinical Heterogeneity in Epidermolysis Bullosa: Speculations on Causation and Consequence for Research.

The article focuses on clinical heterogeneity in epidermolysis bullosa (EB). A recent article presented an extensive review on the role of anchoring fibril changes in dystrophic epidermolysis bullosa, summarizing electron microscopic, biochemical and other evidence. Included were highly relevant points on clinical diagnosis, not the least of which was the difficulty in discriminating the local forms of the recessive type from sporadic dominant mutant cases. The focus in the article is on the clinical variations in different categories of EB, their possible causations, and consequences.