阿伦膦酸钠与阿法骨化醇联合治疗妇女绝经后骨质疏松症的疗效.

Objective: To investigate the clinical effect of alendronate (ALN) combined with alpha ossification in the treatment of in postmenopausal osteoporosis(PMO).Methods:98 cases of PMO patients treated in the outpatient department in our hospital from January 2013 to March 2015 were selected and divided into two groups with the method of random number table.The control group,on the basis of conventional calcium,was given the treatment of alcohol;the observation group,on the basis of the control group,was given ALN treatment.The ward's triangle,femoral neck and lumbar spine L2～L4 bone mineral density (BMD) level,turn,flexion and spontaneous low back pain visual simulation score(VAS),serum bone gla protein(BGP),bone alkaline phosphatase(BALP),type I collagen C telopeptide(CTX) and tartrate resistant acid phosphatase 5b(TRACP-5b) level before and after the treatment,and adverse reactions during medication were recorded and compared between the two groups.Results:In the observation group after the treatment,ward triangle area,the femoral neck and lumbar BMD L2～L4 level compared with those before the treatment,significantly improved (P＜0.05),and the improvement degree of the observation group was more obvious (P＜0.05);as for the patients in the observation group,flexion extension,spontaneous and turning back pain VAS scores compared with those before the treatment significantly decreased (P＜0.01),and the improvement degree of the observation group was more significant (P＜0.01);after the treatment,the serum levels ofBGP,BALP,CTX and TRACP-5b in the observation group significantly decreased compared with those before treatment(P＜0.01),and the improvement degree of the observation group was more significant (P＜0.01).Conclusion:ALN combined with alpha ossification in the treatment of the treatment of PMO can significantly improve the level of BMD,relieve patients' pain symptoms and improve bone metabolism indicators,effectively,safely and reliably,with a high clinical reference value. [ABSTRACT FROM AUTHOR]