SLE 带状疱疹患者外周血CD4+CD28+ 和CD4+CD25+FoxP3+ 调节性T细胞的表达及相关性研究

Objective: To investigate the expression and correlation of CD28 on CD4+/CD8+T cells and Treg cells in peripheral blood of systemic lupus erythematosus (SLE) patients with acute herpes zoster and explore the significance of its change in development of SLE patients with acute herpes zoster. Methods: The expression of CD28 on CD4+/CD8+T cells and frequencies of CD4+CD25+FoxP3+Treg cells were analyzed by flow cytometry in 30 SLE patients,30 SLE patients with acute herpes zoster and 30 healthy controls,the correlation of CD4+CD28+T cells and CD4+CD25+FoxP3+Treg cells was analyzed in SLE patients with acute herpes zoster.Results:It was observed that CD4+,CD4+CD28+,CD8+CD28+T cells were significantly lower and CD4+CD25+FoxP3+Treg cells were significantly higher and CD4+CD25+FoxP3+Treg cells were correlated negatively with CD4+CD28+T cells in the peripheral blood from SLE patients with acute herpes zoster than those in SLE Group and in healthy controls (P＜0.05). Conclusion: The results demonstrate that the decline of T cellular immune function may play a key role in the pathogenesis of herpes zoster. CD4+CD25+FoxP3+Treg cells may be related to the development of SLE with acute herpes zoster. [ABSTRACT FROM AUTHOR]