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Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.

Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.

Authors :
Ge, Yejing
Gomez, Nicholas C.
Adam, Rene C.
Nikolova, Maria
Yang, Hanseul
Verma, Akanksha
Lu, Catherine Pei-Ju
Polak, Lisa
Yuan, Shaopeng
Elemento, Olivier
Fuchs, Elaine
Source :
Cell. May2017, Vol. 169 Issue 4, p636-650.e14. 1p.
Publication Year :
2017

Abstract

Summary Tissue stem cells contribute to tissue regeneration and wound repair through cellular programs that can be hijacked by cancer cells. Here, we investigate such a phenomenon in skin, where during homeostasis, stem cells of the epidermis and hair follicle fuel their respective tissues. We find that breakdown of stem cell lineage confinement—granting privileges associated with both fates—is not only hallmark but also functional in cancer development. We show that lineage plasticity is critical in wound repair, where it operates transiently to redirect fates. Investigating mechanism, we discover that irrespective of cellular origin, lineage infidelity occurs in wounding when stress-responsive enhancers become activated and override homeostatic enhancers that govern lineage specificity. In cancer, stress-responsive transcription factor levels rise, causing lineage commanders to reach excess. When lineage and stress factors collaborate, they activate oncogenic enhancers that distinguish cancers from wounds. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00928674
Volume :
169
Issue :
4
Database :
Academic Search Index
Journal :
Cell
Publication Type :
Academic Journal
Accession number :
122826871
Full Text :
https://doi.org/10.1016/j.cell.2017.03.042