Linkage between insulin and the free radical theory of aging.

Reports that A.L. Lambert and B.J. Merry have provided the first evidence that caloric restriction decreases the mitochondrial proton motive force by increasing the mitochondrial proton leak. Dependence of this leak, at least in part, on plasma insulin levels; Isolation of liver mitochondria from three groups of male rats which are ad libitum-fed, caloric-restricted and caloric-restricted rats supplemented with insulin.