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Differential expression of novel metabolic and immunological biomarkers in oysters challenged with a virulent strain of OsHV-1.
- Source :
-
Developmental & Comparative Immunology . Aug2017, Vol. 73, p229-245. 17p. - Publication Year :
- 2017
-
Abstract
- Early lifestages of the Pacific oyster ( Crassostrea gigas ) are highly susceptible to infection by OsHV-1 μVar, but little information exists regarding metabolic or pathophysiological responses of larval hosts. Using a metabolomics approach, we identified a range of metabolic and immunological responses in oyster larvae exposed to OsHV-1 μVar; some of which have not previously been reported in molluscs. Multivariate analyses of entire metabolite profiles were able to separate infected from non-infected larvae. Correlation analysis revealed the presence of major perturbations in the underlying biochemical networks and secondary pathway analysis of functionally-related metabolites identified a number of prospective pathways differentially regulated in virus-exposed larvae. These results provide new insights into the pathogenic mechanisms of OsHV-1 infection in oyster larvae, which may be applied to develop disease mitigation strategies and/or as new phenotypic information for selective breeding programmes aiming to enhance viral resistance. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENE expression
*CRASSOSTREA
*BIOMARKERS
*VIRUS virulence
*PHENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 0145305X
- Volume :
- 73
- Database :
- Academic Search Index
- Journal :
- Developmental & Comparative Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 122775883
- Full Text :
- https://doi.org/10.1016/j.dci.2017.03.025