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Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis.
- Source :
-
PLoS ONE . 4/27/2017, Vol. 12 Issue 4, p1-15. 15p. - Publication Year :
- 2017
-
Abstract
- Context: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Design: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. Setting: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden). Participants: 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs. Main outcome measures: BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site. Results: 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42–-0.09, p = 2.8*10−3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349). Conclusions: Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OBESITY in men
*TESTOSTERONE
*BLOOD serum analysis
*BLOOD sampling
*BODY mass index
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 122724493
- Full Text :
- https://doi.org/10.1371/journal.pone.0176277