2 型糖尿病患者微血管病变与血清代谢学指标的关系.

Objective: To investigate the relationship between microvascular lesions and serum metabolic parameters in patients with type 2 diabetes mellitus(T2DM). Methods: Selected 96 patients with T2DMin our hospital from July 2015 to July 2016, According to the presence of microvascular lesions were divided into observation group (n=43, with microvascular lesions)and control group(n=53, without microvascular lesions). Detected the levels of triacylglycerol(TG), total cholesterol(TC), high density lipoprotein(HDL), low density lipoprotein (LDL), fasting blood glucose(FBG), glycosylated hemoglobin(HbA1C), homocysteine(Hcy)and serum cystatin C(CysC) and vascular endothelial growth factor (VEGF). Logistic regression analysis was used to analyze the risk factors of microvascular lesions. Results: Course of disease, smoking rate in observation group was higher than the control group, the difference was statistically significant (P<0.05); The levels of TG, LDL, HbA1C, CysC, Hcy, VEGF were higher than the control group, the differences were statistically significant(P<0.05), but the TC and HDL levels in two groups had no significant difference(P>0.05); Logistic regression analysis showed that the course of disease, CysC, Hcy, VEGF were the risk factors for microvascular lesions (OR=1.975, 3.643, 4.054, 4.214, P<0.05). Conclusion: CysC, Hcy, VEGF are the risk factors of the microvascular lesions, detecting these indexes is helpful to diagnosis and treatment of early T2DMwith microvascular lesions. [ABSTRACT FROM AUTHOR]