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Total synthesis of natural spiro-trisindole enantiomers similisines A, B and their stereoisomers.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . May2017, Vol. 58 Issue 20, p1934-1938. 5p. - Publication Year :
- 2017
-
Abstract
- The first total synthesis of similisines A and B, a pair of unprecedented polybrominated spiro-trisindole enantiomers isolated from Laurencia similis , and their all stereoisomers had been accomplished in 6 steps from the known 5,6-dibromoindole. The described synthesis avoided any protecting-group manipulations, and the key all-carbon spirocenters were constructed via an intramolecular Friedel-Crafts cyclization. In addition, the rotamers of similisines and cytotoxic and NO production inhibitory activities of synthetic compounds were also discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 58
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 122698930
- Full Text :
- https://doi.org/10.1016/j.tetlet.2017.03.086