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Sex, alloimmunisation, and susceptibility to HIV infection.
- Source :
-
Lancet . 2/14/2004, Vol. 363 Issue 9408, p503-504. 2p. - Publication Year :
- 2004
-
Abstract
- Presents a commentary on a report in this issue concerning how women who have unprotected sexual intercourse with the same man over a year generate a significant alloimmune response against their partner's leucocytes as compared to third-party leucocytes. Contention that this "immunisation" probably arises via repeated exposure to HLA antigens expressed on leucocytes and epithelial cells in semen and female genital secretions; Additional finding that T cells isolated from the test subjects were resistant to both CCR5 and CXCR4 binding strains of HIV-1 in vitro; Thought by study authors that the concept of mucosal alloimmunisation may be a vaccine strategy to induce protection against HIV-1; Belief that the study raises more questions than it offers clinical applications.
Details
- Language :
- English
- ISSN :
- 01406736
- Volume :
- 363
- Issue :
- 9408
- Database :
- Academic Search Index
- Journal :
- Lancet
- Publication Type :
- Academic Journal
- Accession number :
- 12260776
- Full Text :
- https://doi.org/10.1016/S0140-6736(04)15575-X