Synthesis of (...)-Calicheamicinone by Two Methods.

Characterizes two related techniques for the synthesis of (...)-calicheamicinone, the aglycon of the antitumor antibiotic calichemacin gamma1I. Information on the chemistry and biological properties of calicheamicin gamma1I; Evidence that as a synthetic target, calicheamicin gamma1I represents a large number of complex problems; Development of the synthetic plan; Discussion on the study.