Back to Search
Start Over
Synthesis, Characterization, Speciation, DNA Cleavage, and Cytotoxic Studies of the Pd[2-(2-Aminoethyl)-1-methylpyrrolidine]Cl2 Complex with Reference to Carboplatin.
- Source :
-
European Journal of Inorganic Chemistry . 4/3/2017, Vol. 2017 Issue 13, p1877-1887. 11p. - Publication Year :
- 2017
-
Abstract
- The [Pd(AEMP)Cl2] complex [AEMP = 2-(2-aminoethyl)-1-methylpyrrolidine] was prepared and characterized by single-crystal X-ray diffraction and spectroscopic analyses. The structure of the complex was found to be square-planar with some distortion. The geometric optimizations of the ligand and complex were performed with the DFT/B3LYP method by using Gaussian 09. The stoichiometry and stability constants of the complexes formed in the reaction of [Pd(AEMP)(H2O)2]2+ with dicarboxylic acids and DNA constituents were investigated at 0.1 m ionic strength and 25 °C. The results show that both DNA constituents and cyclobutanedicarboxylate (CBDCA) coordinate to [Pd(AEMP)(H2O)2]2+ to form the quaternary complex [Pd(AEMP)(CBDCA-O)DNA], where CBDCA-O represents cyclobutanedicarboxylate coordinated through one carboxylate oxygen atom to the PdII center. The speciation concentration distributions in solution were evaluated. The biological activity for DNA cleavage and cytotoxicity of the [Pd(AEMP)Cl2] complex was studied. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14341948
- Volume :
- 2017
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- European Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 122380893
- Full Text :
- https://doi.org/10.1002/ejic.201601524