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Synthesis of bromocyclopropylpyridines via the Sandmeyer reaction.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Apr2017, Vol. 58 Issue 17, p1681-1683. 3p. - Publication Year :
- 2017
-
Abstract
- The reactions of 2-amino-5-cyclopropylpyridine with organic nitrites in the presence of copper(II) halides in various organic solvents were investigated. Optimal reaction conditions for the Sandmeyer reaction were developed and successfully applied to the synthesis of useful building blocks, bromo and chlorocyclopropylpyridines. Aminocyclopropylpyridines were synthesized in high yields from the corresponding aminobromopyridines under standard Suzuki coupling conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PYRIDINE synthesis
*CHEMICAL reactions
*NITRITES
*ORGANIC solvents
*SUZUKI reaction
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 58
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 122316395
- Full Text :
- https://doi.org/10.1016/j.tetlet.2017.03.029