ДОСЛІДЖЕННЯ РЕОЛОГІЧНИХ ВЛАСТИВОСТЕЙ ГЕЛІВ, ЩО МІСТЯТЬ НАТРІЮ ДИКЛОФЕНАК

Purpose. To investigate structural and mechanical properties of the gels on a hydrophilic basis containing sodium diclofenac for definition of rheological optimum of a consistence and confirmation of structure of system with the available thixotropy. Methods. Structural and mechanical properties of test samples were studied by reometr of Brookfield DV-III Ultra ("Brookfield Engineering Laboratories", USA) equipped with a spindle - a cone-plate. Results. As a result of researches of rheological properties of gels on a hydrophilic basis containing sodium diclofenac influence of composition of excipients on structural, mechanical and thixotropic properties of disperse systems are established. Scientific novelty. The influence of hydrophobic excipients on structural and mechanical properties of gels on a hydrophilic basis, is researched and compared, it is received rheogram of a flow and dependence of structural viscosity on a shift speed gradient, and also rheological optimum of a consistence of examined gels is studied. Practical importance. Received results allow to confirm that introduction of emulsifiers of a hydroxypropyl methylcellulose and a caprile kaproyl polyoksy hlytseryd to composition of gels on a hydrophilic basis leads to receiving mechanically stable disperse systems having non- Newtonian current type with plastic and thixotropic properties. [ABSTRACT FROM AUTHOR]