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Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Authors :
Bulat, Zorica
Đukić-Ćosić, Danijela
Antonijević, Biljana
Buha, Aleksandra
Bulat, Petar
Pavlović, Zoran
Matović, Vesna
Source :
Archives of Industrial Hygiene & Toxicology / Arhiv za Higijenu Rada I Toksikologiju. Mar2017, Vol. 68 Issue 1, p38-45. 8p.
Publication Year :
2017

Abstract

The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg-1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg-1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00041254
Volume :
68
Issue :
1
Database :
Academic Search Index
Journal :
Archives of Industrial Hygiene & Toxicology / Arhiv za Higijenu Rada I Toksikologiju
Publication Type :
Academic Journal
Accession number :
122281311
Full Text :
https://doi.org/10.1515/aiht-2017-68-2919