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Alkynylation of cyclopropyl trifluoromethyl ketone catalyzed by CuF2ยท2H2O/4,7-diphenyl-1,10-phenanthroline.

Authors :
Liu, Xiao-Dong
Ma, Hai-Yan
Xing, Chun-Hui
Lu, Long
Source :
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Apr2017, Vol. 58 Issue 16, p1564-1567. 4p.
Publication Year :
2017

Abstract

CuF 2 ·2H 2 O/4,7-diphenyl-1,10-phenanthroline was found to be a highly efficient catalyst for the nucleophilic alkynylation of cyclopropyl trifluoromethyl ketone. The corresponding trifluoromethyl-substituted tertiary propargyl alcohols were synthesized in moderate to excellent yields under mild conditions. The catalyst system could also be applied to aromatic trifluoromethyl ketone as well as trifluoropyruvate. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00404039
Volume :
58
Issue :
16
Database :
Academic Search Index
Journal :
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :
Academic Journal
Accession number :
122241084
Full Text :
https://doi.org/10.1016/j.tetlet.2017.03.010