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Serum Endothelial Cell–Specific Molecule 1 (Endocan) Levels in Patients With Acute Myocardial Infarction and Its Clinical Significance.
- Source :
-
Angiology . Apr2017, Vol. 68 Issue 4, p354-359. 6p. - Publication Year :
- 2017
-
Abstract
- Endothelial dysfunction is involved in the process of acute myocardial infarction (AMI), that is, the endothelial cell–specific molecule 1 (ESM-1; endocan) is a novel endothelial dysfunction marker. However, the relationship between patients with AMI and serum ESM-1 levels is not very clear. Patients with AMI (n = 216) and a control group (n = 60) without AMI were included in the study. High-sensitivity C-reactive protein (hsCRP) was measured, and the severity of AMI was assessed by a modified Gensini stenosis scoring system. Serum ESM-1 levels were significantly higher in the AMI group (P < .05). High-sensitivity C-reactive protein levels were also significantly higher in the AMI group (P < .05). In patients with AMI, serum ESM-1 levels were not significantly correlated with hsCRP levels. There was no significant correlation between serum ESM-1 level and Gensini score. Our findings suggest that serum ESM-1 levels may be a novel biomarker of endothelial dysfunction in patients with AMI. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOMARKERS
*BIOCHEMISTRY
*C-reactive protein
*CHI-squared test
*STATISTICAL correlation
*ENZYME-linked immunosorbent assay
*EPITHELIAL cells
*INFLAMMATION
*LONGITUDINAL method
*PHENOMENOLOGY
*MYOCARDIAL infarction
*STATISTICS
*T-test (Statistics)
*PILOT projects
*DATA analysis
*CONTROL groups
*CROSS-sectional method
*DATA analysis software
*DESCRIPTIVE statistics
*CORONARY angiography
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 68
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 122027522
- Full Text :
- https://doi.org/10.1177/0003319716651349