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Pathogenic and Protective Autoantibodies in Autoimmune Polyendocrinopathy-Candidiasis- Ectodermal Dystrophy (APECED).
- Source :
-
Antibodies (2073-4468) . Mar2017, Vol. 6 Issue 1, p1. 13p. - Publication Year :
- 2017
-
Abstract
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare disorder caused by mutations in the autoimmune regulator (AIRE) gene, leading to defects in T cell selection. The disease manifestations include both autoimmune tissue destruction and immunodeficiency, with specific susceptibility to chronic mucocutaneous candidiasis. Studies have demonstrated a wide repertoire of high affinity tissue- and cytokine-specific antibodies in patients with APECED. Here, we review the antigenic targets and function of these disease-causing and disease-ameliorating antibodies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20734468
- Volume :
- 6
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Antibodies (2073-4468)
- Publication Type :
- Academic Journal
- Accession number :
- 122026797
- Full Text :
- https://doi.org/10.3390/antib6010001