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Il ruolo della galectina-3 nella patologia cardio-renale.
- Source :
-
Giornale di Tecniche Nefrologiche e Dialitiche . Jan-Mar2017, Vol. 29 Issue 1, p50-58. 9p. - Publication Year :
- 2017
-
Abstract
- Galectin-3 is a 32- to 35-kDa member of the galectin family of b-galactoside-binding lectins, which is characterized by a carbohydrate recognition domain. Through its carbohydrate-binding function, it regulates cell growth, differentiation, and inflammation. It also plays a complex, context-dependent role in the kidneys. During the development, it promotes nephrogenesis and is strongly expressed in the ureteric bud and its derivatives. An increase in the concentration of galectin-3 has been reported to be associated with fibrosis of the kidneys. Elevated levels of plasma galectin-3 are also associated with increased risks of rapid renal function decline, incident chronic kidney disease, and progressive renal impairment, and also with cardiovascular endpoints, infection, and all-cause mortality in patients with renal function impairment. This review discusses a general survey on galectin-3 expressions in nephrogenesis, kidney injury in animal models, clinical renal diseases, and renal transplantation and the potential role of galectin-3 for treatment in kidney disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Italian
- ISSN :
- 03949362
- Volume :
- 29
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Giornale di Tecniche Nefrologiche e Dialitiche
- Publication Type :
- Academic Journal
- Accession number :
- 121988122
- Full Text :
- https://doi.org/10.5301/GTND.2017.16573