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Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes.
- Source :
-
Cancer Investigation . 2017, Vol. 35 Issue 3, p174-186. 13p. - Publication Year :
- 2017
-
Abstract
- We investigated the effect of chrysin on isolated normal and chronic lymphocytic leukemia (CLL) B-lymphocytes and their isolated mitochondria. We report that a selective and significant increase in cytotoxicity, intracellular reactive oxygen species, mitochondrial membrane potential collapse, ADP/ATP ratio, caspase 3 activation and finally apoptosis in chrysin-treated CLL B- lymphocytes. Also we determined that chrysin selectively inhibits complex II and ATPases in cancerous mitochondria. In this study we proved that the ability of chrysin to promote apoptosis in CLL B-lymphocytes performed by selectively targeting of mitochondria. Our findings may provide a potential therapeutic approach for using chrysin to target mitochondria in CLL B-lymphocytes. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *ANTINEOPLASTIC agents
*LYMPHOCYTIC leukemia
*MITOCHONDRIA
*APOPTOSIS
*REACTIVE oxygen species
*LEUKEMIA treatment
*ADENOSINE triphosphate metabolism
*PROTEIN metabolism
*ADENOSINE diphosphate
*ADENOSINE triphosphatase
*B cells
*BIOLOGICAL transport
*CARRIER proteins
*CELL physiology
*CHRONIC lymphocytic leukemia
*DRUG design
*CLINICAL drug trials
*ENERGY metabolism
*FLAVONOIDS
*MEMBRANE proteins
*PROTEINS
*CANCER cell culture
*CHEMICAL inhibitors
*PHARMACODYNAMICS
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 35
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 121886436
- Full Text :
- https://doi.org/10.1080/07357907.2016.1276187