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Optical coherence tomography analysis of hydrofluoric acid decontamination of human cornea by mannitol solution.
- Source :
-
Burns (03054179) . Mar2017, Vol. 43 Issue 2, p424-428. 5p. - Publication Year :
- 2017
-
Abstract
- <bold>Purpose: </bold>To evaluate the efficacy of mannitol solution as a decontamination agent on the chemical burn of the human corneas.<bold>Methods: </bold>Eight donor corneas from an eye bank were exposed to 25μl of 2.5% hydrofluoric acid (HF) solution on a filter paper for 20s. Three eyes were rinsed with 1000ml of mannitol 20% for 15min immediately after removal of the filter paper, 3 other were rinsed with sodium chloride (NaCl) 0.9% (1000ml for 15min) and two eyes were not rinsed. Microstructural changes were monitored in the time domain by optical coherence tomography (OCT) imaging for 75min.<bold>Results: </bold>NaCl reduced the penetration depth to approximately half the thickness of the cornea at 15min; scattering within the anterior cornea was higher than that for the unrinsed eye. With mannitol, no increased scattering was observed in the posterior part of the corneal stroma within a time period of 1h after rinsing. OCT images revealed low-scattering intensity within the anterior stroma at the end of the rinsing period.<bold>Conclusion: </bold>In eye bank human corneas, mannitol proved to be an efficient agent to decontaminate HF burn. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03054179
- Volume :
- 43
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Burns (03054179)
- Publication Type :
- Academic Journal
- Accession number :
- 121784733
- Full Text :
- https://doi.org/10.1016/j.burns.2016.08.012