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Thin liquid films from a new synthetic pulmonary surfactant preparation.

Authors :
Todorov, Roumen
Exerowa, Dotchi
Alexandrova, Lidia
Platikanov, Dimo
Nedyalkov, Michail
Bianco, Federico
Razzetti, Roberta
Salomone, Fabrizio
Pelizzi, Nicola
Source :
Colloids & Surfaces A: Physicochemical & Engineering Aspects. Apr2017, Vol. 519, p20-26. 7p.
Publication Year :
2017

Abstract

A new pulmonary surfactant with synthetic analogs of surfactant proteins SP-B and SP-C (CHF5633) was studied by the method of thin liquid films (foam and wetting films). For foam films dependences such as probability W for formation of black foam films vs. surfactant concentration ( C s ), disjoining (capillary) pressure isotherms (Π( h )) and film thickness ( h ) were studied. The minimum CHF5633 concentration for a black foam film formation was established in 75 μg/cm 3 (after 30 min). The results obtained were compared with those of therapeutic pulmonary surfactant preparations and in particular to Curosurf ® , the one that showed the best profile among the tested animal-derived surfactants with respect to black film formation, stability and homogeneity. It was shown that with respect to stability surfactant CHF 5633 (from W/C curves) was very close to Curosurf ® . The differences involved black foam film thicknesses which for the synthetic surfactant (at 200 μg/cm 3 ) were h = 14.7 nm and for Curosurf ® (at 200 μg/cm 3 ), h = 12.6 nm, i.e. film thickness of the synthetic surfactant was larger, probably due to the larger quantities of surfactant protein analogs SP-B and SP-C contained in it and/or to the different phospholipid composition. The same was observed for h ( C s ) dependence. For wetting films equilibrium thickness vs. degree of hydrophobicity on a solid surface was measured as well as wetting contact angles. Practically no significant difference in the wetting behaviour of the aqueous suspensions of natural surfactant preparation Curosurf ® and CHF 5633 was established, however about 25% less Curosurf ® was needed to achieve almost the same wetting behavior. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09277757
Volume :
519
Database :
Academic Search Index
Journal :
Colloids & Surfaces A: Physicochemical & Engineering Aspects
Publication Type :
Academic Journal
Accession number :
121753445
Full Text :
https://doi.org/10.1016/j.colsurfa.2016.06.010