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Ir-Catalyzed Asymmetric Total Synthesis of (-)-Communesin F.
- Source :
-
Journal of the American Chemical Society . 3/8/2017, Vol. 139 Issue 9, p3364-3367. 4p. - Publication Year :
- 2017
-
Abstract
- The first catalytic asymmetric total synthesis of the heptacyclic alkaloid (-)-communesin F is described. A key step features an iridium-catalyzed asymmetric intermolecular cascade cyclization, constructing the lower N,N-aminal-containing CDEF tetracyclic core in one step. Another notable element is the closure of final ring system (A ring) via a facile reduction of a twisted amide and concomitant cyclization activated by mesylation of N,O-hemiaminal intermediate. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IRIDIUM catalysts
*ASYMMETRIC synthesis
*ORGANIC compounds
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 139
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 121727856
- Full Text :
- https://doi.org/10.1021/jacs.7b00854