Beta Talasemi Hastalarında Serum Paraoksonaz Aktivitesi İle Biyokimyasal Parametreler Arasındaki İlişki.

Objective: Beta thalassemia (β-Thal) is a chronic anemia in which while oxidants stress increases, antioxidant capacity decreases. Paroxanase is an enzyme having antioxidant properties. In this study we searched markers effecting paroxanase activity in β-Thal patients. Materials and Methods: In this study we measured serum paroxanase activity, complete blood count, fasting glucose, BUN, creatinin, sodium, potassium, chloride, calcium, AST, ALT, LDH, albumin, globulin, uric acid, indirect bilirubin, direct bilirubin, TSH, parathyroid hormone, ferritin, and vitamin B12 in 46 β-Thal patients. Results: We found that there is a significant correlation between serum paroxanase activity, serum chloride level, and serum TSH (r=0.319, p<0.05). There is no significant correlation between serum paroxanase activity and other parameters. Conclusion: Thyroid disorders and diseases effecting chloride levels do not effect serum paroxanase activity in β-Thal patients. [ABSTRACT FROM AUTHOR]