CD127 Expression in Naive and Memory T Cells in HIV Patients Who Have Undergone Long-Term HAART.

Objective: To evaluate cluster of differentiation (CD)127 expression in T cells of patients with HIV-1 and the relationship of CD127 expression with disease progression. Methods: We divided 139 patients infected with human immunodeficiency virus type 1 (HIV-1) who had undergone highly active antiretroviral therapy (HAART) into 3 groups: patients with poor recovery (CD4+T<350/mL, patients with general recovery (CD4+ T= 350 - ~600/µL) and patients with good recovery (CD4+ T>600/µL). Counts and percentages of naïve (CD45RA+) and memory (CD45RO+) T cells and CD127 expression were determined using flow cytometry. Results: CD4+ CD45RO+, CD4+ CD45RA+, CD4+ CD45RO+ CD127+, and CD4+ CD45RA+ CD127+ T-cell counts in patients with good recovery were higher than in patients with poor recovery and those with general recovery patients (P <.05). Percentages of CD45RO+ were increased, and percentages of CD45RA+ and CD127 in T cells were decreased in patients with poor and general recovery (P <.05). CD127 values were positively correlated with CD4+ T-cell counts and percentages of CD45RA+ subsets (P <.05). Conclusion: CD127 expression in T cells is decreased in patients with HIV-1 and is related to recovery of CD4+ T-cell counts and to naïve subsets. [ABSTRACT FROM AUTHOR]