Synthesis of 8-aryl-3,5,7,3′,4′-penta-O-methylcyanidins from the corresponding quercetin derivatives by reduction with LiAlH4.

Synthesis of 8-aryl-3,5,7,3′,4′- penta - O -methylcyanidins from the corresponding quercetin derivatives by reduction with LiAlH 4 is reported. Regioselective iodination at the 8-position of penta - O -methylquercetin followed by a Suzuki-Miyaura reaction gave the 8-arylated quercetin derivatives. By the reduction of 8-arylated quercetins using 4 equiv. of LiAlH 4 at room temperature for 30 min, the corresponding anthocyanidins were obtained with a good yield. [ABSTRACT FROM AUTHOR]