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自噬-溶酶体途径与骨骼肌和膈肌萎缩的研究进展.
- Source :
-
Fudan University Journal of Medical Sciences . Jan2017, Vol. 44 Issue 1, p99-104. 6p. - Publication Year :
- 2017
-
Abstract
- Skeletal muscles are the body′s agent of motion and important sites for the control of metabolism. The respiratory muscles are unique among skeletal muscles, since they must work without sustained rest throughout life. The diaphragm is the principal inspiratory pump muscle,it is more resistant to developing fatigue than limb muscles. The blood flow and the oxidative capacity of the diaphragm exceed those of limb muscles. Muscle atrophy and contractile dysfunction can be found in a variety of diseases. The reductions in muscle mass is tilted toward reduced protein synthesis and enhanced protein degradation. During pathologic conditions, enhanced protein breakdown is the main reason resulting in myofiber atrophy. Recent studies have underlined a critical role for the autophagy-lysosome (AL) system in regulating muscle mass. The main function of AL system involves the delivery of cytoplasmic cargo sequestered inside double-membrane vesicles to the lysosome which can eliminate the cell of superfluous or damaged organelles and proteins. Basal autophagy is necessary to muscle homeostasis, since it is responsible for the removal of intracellular metabolites. But excessive activation of autophagy can aggravate catabolism and contribute to muscle loss. This review focuses on the AL system and discusses its beneficial or detrimental role in skeletal and diaphragm atrophy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Chinese
- ISSN :
- 16728467
- Volume :
- 44
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Fudan University Journal of Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 121227768
- Full Text :
- https://doi.org/10.3969/j.issn.1672-8467.2017.01.017