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Hydro-ethanolic Extract of Portulaca oleracea Affects Beta-adrenoceptors of Guinea Pig Tracheal Smooth Muscle.

Authors :
Boskabady, Mohammad Hossein
Hashemzehi, Milad
Khazdair, Mohammad Reza
Askari, Vahid Reza
Source :
Iranian Journal of Pharmaceutical Research. Autumn2016, Vol. 15 Issue 4, p867-874. 8p.
Publication Year :
2016

Abstract

Thestimulatory effect of the extract of Portulaca oleracea (P. olerace) on β-adrenoceptor of tracheal smooth muscle was examined. To examine β-adrenoceptor stimulatory effect, concentration response curve to isoprenaline was obtained in pre-contracted tracheal smooth muscle in the presence of three concentrations of aqueous-ethanolic extract, propranolol, and saline. Values of EC50 (the effective concentration of isoprenaline, causing 50% of maximum response) and dose ratio-1(CR-1) were measured. This effect was tested innon-incubated tracheal smooth muscle (group 1) and incubated tissues with chlorpheniramine (group 2). Concentration-response curves to isoprenaline in the presence of two higher concentrations of the extract in group 1 and all three concentrations in group 2 showed leftward shifts compared to isoprenaline curves produced in the presence of saline in both groups. EC50 obtained in the presence of propranolol was significantly higher than that of saline in both groups of experiments (p<0.05 for both cases). However, the EC50 obtained in the presence of two higher concentrations of the extract in group 1 and lower concentration in group 2 were nonsignificantly but those obtained of medium and high extract concentrations in the group 2 were significantly (p<0.05 for both cases)lower than those of saline. The values of (CR-1) obtained in the presence of all concentrations of the extract in groups1 and 2 were significantly lower than that of propranolol (p<0.05 to p<0.001).The results indicated a stimulatory effect of the P. olerace extract on ß2-adrenoceptors of tracheal smooth muscle. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17350328
Volume :
15
Issue :
4
Database :
Academic Search Index
Journal :
Iranian Journal of Pharmaceutical Research
Publication Type :
Academic Journal
Accession number :
121211194