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Zn-containing radiopharmaceuticals: a novel approach to molecular design.
- Source :
-
Journal of Radioanalytical & Nuclear Chemistry . Feb2017, Vol. 311 Issue 2, p1177-1183. 7p. - Publication Year :
- 2017
-
Abstract
- Zn was produced and separated for medical applications. Possibilities and perspectives for production of radiopharmaceuticals based on Zn containing derivatives of thiazine, thiazoline and thiourea are considered. Each one of the latters is a zinc chelator and a nitric oxide synthase (NOS) effector at the same time. Cytotoxic effect of NOS activator and NOS inhibitors are shown in experiments with HL-60, K-562 and MOLT-4 cell lines and in bone marrow cells of the acute B-lymphoblastic leukemia patients. Some of those compounds are worthy to get selected for further application as radiopharmaceuticals including their antitumor speciements. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 311
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 121149031
- Full Text :
- https://doi.org/10.1007/s10967-016-5076-y