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Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection.
- Source :
-
Hepatology Research . Feb2017, Vol. 47 Issue 2, p226-233. 8p. - Publication Year :
- 2017
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Abstract
- Aim Serum glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) is a reliable, non-invasive marker of liver fibrosis. This study assessed the ability of WFA+-M2BP to diagnose liver fibrosis in patients with chronic hepatitis B virus (HBV) infection and evaluated WFA+-M2BP as a predictor of hepatocellular carcinoma (HCC) development. Methods Serum WFA+-M2BP values were retrospectively evaluated in 112 treatment-naïve patients with HBV-related chronic hepatitis and cirrhosis who had undergone liver biopsy at our hospital. Results Serum WFA+-M2BP levels were significantly related with liver fibrosis (r = 0.3725, P = 0.001). Fibrosis stage F2, F3, and F4 had a cut-off index of 0.94, 1.26, and 1.26, respectively. For diagnosing F ≥ 2 fibrosis, the area under the receiver-operating characteristic curve for WFA+-M2BP was 0.713 and comparable with those of other non-invasive fibrosis markers, such as hyaluronic acid, type IV collagen 7S, aspartate aminotransferase-to-platelet ratio index, fibrosis-4 index, serum albumin, and platelet count. Multivariate analysis identified male, WFA+-M2BP ≥0.71, alanine aminotransferase ≥80 IU/L, and platelet count <14.5 × 109/L as independent risk factors for the development of HCC in patients with HBV infection. Conclusions Serum WFA+-M2BP values appear to be useful for assessing liver fibrosis stage and are independently associated with HCC development in patients with chronic HBV infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13866346
- Volume :
- 47
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Hepatology Research
- Publication Type :
- Academic Journal
- Accession number :
- 121082633
- Full Text :
- https://doi.org/10.1111/hepr.12712