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Indoor Tanning and Melanoma Risk: Long-Term Evidence From a Prospective Population-Based Cohort Study.
- Source :
-
American Journal of Epidemiology . 2/1/2017, Vol. 185 Issue 3, p147-156. 10p. - Publication Year :
- 2017
-
Abstract
- Indoor tanning is associated with increased risk of melanoma, but most evidence comes from case-control studies. Using data from the Norwegian Women and Cancer Study, a large prospective cohort study, we investigated the associations of age at initiation of indoor tanning, duration of tanning-device use, and dose response with melanoma risk and examined the role of indoor tanning in age at melanoma diagnosis. We used Poisson regression to estimate relative risks and 95% confidence intervals for the relationship of indoor tanning to melanoma risk and linear regression to examine age of indoor tanning initiation in relation to age at diagnosis. During follow-up of 141,045 women (1991-2012; mean duration follow-up = 13.7 years), 861 women were diagnosed with melanoma. Melanoma risk increased with increasing cumulative number of tanning sessions (for highest tertile of use vs. never use, adjusted relative risk = 1.32, 95% confidence interval (CI): 1.08,1.63); P-trend = 0.006. Age at initiation <30 years was associated with a higher risk in comparison with never use (adjusted relative risk = 1.31, 95% CI: 1.07, 1.59). Moreover, women who started indoor tanning prior to 30 years of age were 2.2 years (95% CI: 0.9, 3.4) younger at diagnosis, on average, than never users. This cohort study provides strong evidence of a dose-response association between indoor tanning and risk of melanoma and supports the hypothesis that vulnerability to the harmful effects of indoor tanning is greater at a younger age. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MELANOMA
*AGE distribution
*CONFIDENCE intervals
*LONGITUDINAL method
*PROBABILITY theory
*QUESTIONNAIRES
*REGRESSION analysis
*RESEARCH funding
*STATISTICAL hypothesis testing
*ULTRAVIOLET radiation
*SUNBURN
*DATA analysis software
*DESCRIPTIVE statistics
*DISEASE complications
*CANCER risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 185
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 121071824
- Full Text :
- https://doi.org/10.1093/aje/kww148